Smart Polymers: Principles and Applications (De Gruyter STEM)
By José Miguel García, Félix Clemente García, José Antonio Reglero Ruiz, Saúl Vallejos and Miriam Trigo-López
Contents:
1 General introduction and preface 1
2 Fundamentals of smart polymers 3
2.1 Introduction 3
2.2 Response to physical stimuli 5
2.2.1 Temperature as stimulus 5
2.2.2 Light as stimulus 6
2.2.3 Electrical stimuli 6
2.2.4 Mechanical stress as stimulus 7
2.3 Response to chemical stimuli 7
2.3.1 Chemical species as stimulus 7
2.3.2 pH as stimulus 8
2.3.3 Solvent as stimulus 8
2.3.4 Redox as stimulus 8
2.3.5 Varied stimuli that trigger controlled depolymerization 9
2.4 Response to biological stimuli 9
2.4.1 Polymer-based biosensors 9
2.4.2 Drug delivery 10
2.4.3 Tissue engineering 10
2.4.4 Precision medicine and cell therapy 11
2.5 Multiple stimuli-responsive polymers 11
3 Sensory polymers 12
3.1 Introduction 12
3.2 Classification of sensory polymers by stimulus 13
3.2.1 Chemical stimuli: targets 13
3.2.2 Physical stimuli 15
3.3 Classification of sensory polymers by mechanism 16
3.3.1 Reversible mechanism-based sensory polymers 16
3.3.2 Irreversible mechanism-based sensory polymers 20
3.4 Classification of sensory polymers by response 24
3.4.1 Colorimetric sensory polymers 24
3.4.2 Fluorometric sensory polymers 25
3.4.3 Electrochemical sensory polymers 26
3.5 List of the most relevant sensory polymers sorted by application 29
3.6 Immobilization of biomolecules 31
3.6.1 Introduction 31
3.6.2 Smart polymers for the immobilization of biomolecules 36
4 Emerging applications of smart polymers in biomedicine 51
4.1 Introduction 51
4.2 Drug delivery 51
4.2.1 Introduction 51
4.2.2 Polymers for drug delivery 53
4.2.3 Stimuli-responsive polymers 55
4.3 Tissue engineering 81
4.3.1 Introduction 81
4.3.2 Materials for smart hydrogels 85
4.3.3 Stimuli-responsive hydrogels in tissue regeneration 89
4.3.4 Recent developments and applications 92
4.4 Precision medicine and cell therapy 97
4.4.1 Introduction 97
4.4.2 Precision medicine 97
4.4.3 Cell therapy 103
5 Conclusions, challenges and perspectives 112
References 115
Index 141