Cognitive Neuroscience: The Biology of the Mind, 5th Edition PDF by Michael, Richard and George

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Cognitive Neuroscience: The Biology of the Mind, 5th Edition

Michael S. Gazzaniga, Richard B. Ivry and George R. Mangun

Cognitive Neuroscience

Contents

PART I Background and Methods

1 A Brief History of Cognitive

Neuroscience 2

1.1 A Historical Perspective 4

1.2 The Brain Story 6

Box 1.1 Lessons From the Clinic: Fits and Starts 8

1.3 The Psychological Story 11

1.4 The Instruments of Neuroscience 14

Electroencephalography 15

Measuring Blood Flow in the Brain 15

Computerized Axial Tomography 15

Positron Emission Tomography and

Radioactive Tracers 16

Magnetic Resonance Imaging 17

Functional Magnetic Resonance Imaging 17

1.5 The Book in Your Hands 19

2 Structure and Function of the

Nervous System 22

2.1 The Cells of the Nervous System 24

Glial Cells 24

Neurons 26

Neuronal Signaling 28

2.2 Synaptic Transmission 33

Chemical Transmission 33

Electrical Transmission 38

2.3 Overview of Nervous System Structure 39

The Autonomic Nervous System 40

The Central Nervous System 41

Blood Supply and the Brain 42

Box 2.1 The Cognitive Neuroscientist’s Toolkit:

Navigating the Brain 43

2.4 A Guided Tour of the Brain 45

The Spinal Cord 45

The Brainstem: Medulla, Pons, Cerebellum,

and Midbrain 46

The Diencephalon: Thalamus and

Hypothalamus 48

The Telencephalon: Cerebrum 49

2.5 The Cerebral Cortex 52

Dividing the Cortex by Surface Features 53

Dividing the Cortex by Cell Architecture 54

Dividing the Cortex by Function 56

Box 2.2 Lessons From the Clinic: Cortical

Topography 59

2.6 Connecting the Brain’s Components into

Systems 62

2.7 Development of the Nervous System 63

Overview of Early Development 63

The Baby Brain: Ready to Rock ’n’ Roll? 67

Birth of New Neurons Throughout Life 67

3 Methods of Cognitive

Neuroscience 72

3.1 Cognitive Psychology and Behavioral

Methods 74

Mental Representations 75

Internal Transformations 76

Constraints on Information Processing 78

3.2 Studying the Damaged Brain 79

Causes of Neurological Dysfunction 79

Box 3.1 The Cognitive Neuroscientist’s Toolkit:

Single and Double Dissociations 83

Studying Brain–Behavior Relationships

Following Neural Disruption 83

3.3 Methods to Perturb Neural Function 85

Pharmacology 85

Genetic Manipulations 86

Box 3.2 Lessons From the Clinic:

Brain Size → PTSD, or PTSD → Brain Size? 87

Invasive Stimulation Methods 88

Noninvasive Stimulation Methods 89

3.4 Structural Analysis of the Brain 93

Visualizing the Gross Anatomy of the Brain 93

Visualizing the Structural Connectivity

of the Brain 95

3.5 Methods to Measure Neural Activity 96

Single-Cell Neurophysiology in Animals 96

Invasive Neurophysiology in Humans 98

Noninvasive Electrical Recording of Neural

Activity 100

3.6 The Marriage of Function and Structure:

Neuroimaging 104

Positron Emission Tomography 105

Functional Magnetic Resonance

Imaging 106

Limitations of Functional Imaging

Techniques 110

3.7 Connectivity Maps 111

3.8 Computational Neuroscience 116

Representations in Computer Models 117

Models Lead to Testable Predictions 117

3.9 Converging Methods 118

PART II Core Processes

4 Hemispheric Specialization 124

4.1 Anatomical Correlates of Hemispheric

Specialization 127

Macroscopic Anatomical

Asymmetries 127

Box 4.1 The Cognitive Neuroscientist’s Toolkit:

The Wada Test 128

Microscopic Anatomical Asymmetries 129

Anatomy of Communication: The Corpus

Callosum and the Commissures 131

Function of the Corpus Callosum 133

4.2 Splitting the Brain: Cortical

Disconnection 135

The Surgery in Humans 135

Methodological Considerations in Studying

Split-Brain Patients 136

Functional Consequences of the Split-Brain

Procedure 137

4.3 Evidence of Lateralized Brain Functions from

Split-Brain Patients 139

Language and Speech 140

Visuospatial Processing 142

The Interactions of Attention

and Perception 145

Theory of Mind 150

4.4 The Interpreter 151

Box 4.2 Lessons From the Clinic: The Maine

Idea 156

4.5 Evidence of Lateralized Brain Functions from

the Normal and Malfunctioning Brain 156

Mapping Functional and Anatomical

Connectivity 158

Abnormal Hemispheric Lateralization 158

4.6 The Evolutionary Basis of Hemispheric

Specialization 159

Hemispheric Specialization

in Nonhumans 159

The Brain’s Modular Architecture 161

Hemispheric Specialization: A Dichotomy in

Function or Stylishly Different? 163

Is There a Connection Between Handedness

and Left-Hemisphere Language

Dominance? 164

5 Sensation and Perception 168

5.1 Senses, Sensation, and Perception 170

Common Processing Across the

Senses 170

Sensory Receptors 171

Connective Similarities 173

5.2 Olfaction 173

Neural Pathways of Olfaction 174

The Role of Sniffi ng 175

The Nose Knows 176

5.3 Gustation 177

Neural Pathways of Gustation 177

Gustatory Processing 178

Gustotopic Maps 179

5.4 Somatosensation 181

Neural Pathways of Somatosensation 181

Somatosensory Processing 182

Plasticity in the Somatosensory

Cortex 183

5.5 Audition 184

Neural Pathways of Audition 184

Box 5.1 Lessons From the Clinic: The Invisible

Hand 185

Auditory Cortex 187

Computational Goals in Audition 188

5.6 Vision 190

Neural Pathways of Vision 190

Visual Cortex 192

5.7 From Sensation to Perception 200

Where Are Percepts Formed? 200

Defi cits in Visual Perception 203

5.8 Multimodal Perception: I See What

You’re Sayin’ 206

How Does Multimodal Processing

Happen? 206

Where Does Multimodal Processing

Happen? 207

Errors in Multimodal Processing:

Synesthesia 209

5.9 Perceptual Reorganization 210

Development of Sensory Systems 211

Perceptual Reorganization Secondary to

Early Sensory Loss 211

Cortical Reorganization Over Shorter Time

Spans 213

Mechanisms of Cortical Reorganization 215

5.10 Engineering for Compensation 216

Cochlear Implants 216

Box 5.2 Hot Science: Not-So-Blind Mice 217

Retinal Implants 217

6 Object Recognition 222

6.1 Computational Problems in Object

Recognition 224

6.2 Multiple Pathways for Visual

Perception 226

The “What” and “Where” Pathways 227

Representational Differences Between

the Dorsal and Ventral Streams 228

Perception for Identifi cation Versus

Perception for Action 229

Box 6.1 Lessons From the Clinic: The Day the

Music Died 230

6.3 Seeing Shapes and Perceiving Objects 233

Shape Encoding 233

From Shapes to Objects 236

Grandmother Cells and Ensemble

Coding 237

Exploiting the Computational Power

of Neural Networks 239

Top-Down Effects on Object

Recognition 240

Mind Reading: Decoding and Encoding Brain

Signals 242

Box 6.2 Hot Science: A Wild and Crazy Future for

Mind Reading 248

6.4 Specifi city of Object Recognition in Higher

Visual Areas 248

Is Face Processing Special? 249

Diving Deeply Into Facial Perception 253

Does the Visual System Contain Other

Category-Specifi c Systems? 254

Testing Causality 256

6.5 Failures in Object Recognition 259

Subtypes of Visual Agnosia 259

Organizational Theories of Category

Specifi city 261

Developmental Origins of Category

Specifi city 264

6.6 Prosopagnosia Is a Failure to Recognize

Faces 265

Developmental Disorders With Face

Recognition Defi cits 265

Processing Accounts of Prosopagnosia 268

7 Attention 274

7.1 Selective Attention and the Anatomy of

Attention 276

7.2 The Neuropsychology of Attention 278

Neglect 278

Comparing Neglect and Bálint’s

Syndrome 281

7.3 Models of Attention 282

Hermann von Helmholtz and Covert

Attention 282

The Cocktail Party Effect 283

Early-Selection Models Versus Late-Selection

Models 284

Quantifying the Role of Attention in

Perception 285

7.4 Neural Mechanisms of Attention and

Perceptual Selection 287

Voluntary Visuospatial Attention 287

Refl exive Visuospatial Attention 296

Visual Search 297

Feature Attention 300

Object Attention 304

7.5 Attentional Control Networks 308

The Dorsal Attention Network 309

Box 7.1 Hot Science: A Thinking Cap? 313

The Ventral Attention Network 316

Subcortical Components of Attentional

Control Networks 317

8 Action 324

8.1 The Anatomy and Control of Motor

Structures 327

Muscles, Motor Neurons, and the Spinal

Cord 328

Subcortical Motor Structures 330

Cortical Regions Involved in Motor

Control 331

8.2 Computational Issues in Motor

Control 335

Central Pattern Generators 336

Central Representation of Movement

Plans 337

Hierarchical Representation of Action

Sequences 337

8.3 Physiological Analysis of Motor Pathways 339

Neural Coding of Movement 339

Alternative Perspectives on Neural Representation

of Movement 342

8.4 Goal Selection and Action Planning 345

Action Goals and Movement Plans 345

Representational Variation Across Motor

Areas of the Cortex 347

8.5 Links Between Action and

Perception 350

8.6 Recouping Motor Loss 352

Regaining Movement After Loss of Motor

Cortex 352

The Brain–Machine Interface 353

8.7 Movement Initiation and the Basal

Ganglia 359

The Basal Ganglia as a Gatekeeper 359

The Basal Ganglia and Learning 360

Disorders of the Basal Ganglia 361

Direct Stimulation of the Basal

Ganglia 364

8.8 Learning and Performing

New Skills 365

Shift in Cortical Control With

Learning 366

Adaptive Learning Through Sensory

Feedback 366

Neural Mechanisms of Adaptation 367

Error-Based Learning From Forward

Models 369

Box 8.1 Hot Science: Snooping Around in the

Cerebellum 371

Expertise 371

9 Memory 378

9.1 Learning and Memory, and Their Associated

Anatomy 380

9.2 Memory Defi cits: Amnesia 382

Brain Surgery and Memory Loss 382

Dementias 383

9.3 Mechanisms of Memory 384

Short-Term Forms of Memory 384

Long-Term Forms of Memory 389

9.4 The Medial Temporal Lobe Memory

System 396

Evidence From Amnesia 396

Evidence From Animals With Medial

Temporal Lobe Lesions 399

9.5 Distinguishing Human Memory Systems

With Imaging 403

Recollection and Recognition: Two

Systems 403

Long-Term Memory Storage and Retrieval 408

Encoding, Retrieval, and the Frontal Cortex 411

Retrieval and the Parietal Cortex 413

9.6 Memory Consolidation 416

Consolidation and the Hippocampus 416

Sleep and Memory Consolidation 417

Stress and Memory Consolidation 418

9.7 Cellular Basis of Learning and Memory 418

Long-Term Potentiation and the

Hippocampus 419

Box 9.1 Hot Science: I Know You’re in There! 421

Long-Term Potentiation and Memory

Performance 422

10 Emotion 426

10.1 What Is an Emotion? 428

Box 10.1 Hot Science: Tech Stress 430

10.2 Neural Systems Involved in Emotion

Processing 431

Early Concepts: The Limbic System as the

Emotional Brain 432

Emerging Concepts of Emotional

Networks 433

10.3 Categorizing Emotions 434

Basic Emotions 435

Complex Emotions 437

Dimensional Theories of Emotion 438

10.4 Theories of Emotion Generation 439

James–Lange Theory of Emotion 440

Cannon–Bard Theory of Emotion 440

Appraisal Theory of Emotion 441

Singer–Schachter Theory: Cognitive

Interpretation of Arousal 441

LeDoux’s Fast and Slow Roads to

Emotion 441

Evolutionary Psychology Approach to

Emotion 442

Panksepp’s Hierarchical-Processing Theory

of Emotion 442

Anderson and Adolphs: Emotions as Central

Causative States 443

10.5 The Amygdala 443

10.6 The Infl uence of Emotion on Learning 445

Implicit Emotional Learning 445

Explicit Emotional Learning 450

10.7 Interactions Between Emotion and Other

Cognitive Processes 454

The Infl uence of Emotion on Perception

and Attention 454

Emotion and Decision Making 456

10.8 Emotion and Social Stimuli 459

Facial Expressions 459

Beyond the Face 461

Social Group Evaluation 462

10.9 Other Areas, Other Emotions 464

The Insular Cortex 464

Disgust 465

Happiness 466

Love 466

10.10 Get a Grip! Cognitive Control of

Emotion 468

11 Language 474

1 1.1 The Anatomy of Language and Language

Defi cits 476

Brain Damage and Language Defi cits 477

Box 11.1 The Cognitive Neuroscientist’s Toolkit:

Stimulation Mapping of the Human Brain 478

Box 11.2 Lessons From the Clinic: Genetic

Foundations of Language 479

The Wernicke–Lichtheim Model of Brain and

Language 481

11.2 The Fundamentals of Language in the

Human Brain 482

Organization of the Mental Lexicon 483

Models of the Mental Lexicon 484

Neural Substrates of the Mental

Lexicon 484

Box 11.3 Hot Science: Semantic Maps in the

Brain 485

11.3 Language Comprehension: Early Steps 488

Spoken Input: Understanding Speech 489

Written Input: Reading Words 492

11.4 Language Comprehension: Later Steps 496

The Role of Context in Word

Recognition 496

Integration of Words into Sentences 498

Semantic Processing and the N400

Wave 498

Syntactic Processing and the P600

Wave 500

11.5 Neural Models of Language

Comprehension 503

Networks of the Left-Hemisphere Perisylvian

Language System 504

11.6 Neural Models of Speech Production 505

Motor Control and Language

Production 505

Psycholinguistic Models of Speech

Production 505

Neural Substrates of Language

Production 506

11.7 Evolution of Language 508

Shared Intentionality 508

Gesture and Communication 509

Left-Hemisphere Dominance and

Specialization 510

PART III Control Processes

xviii | Contents

12 Cognitive Control 514

12.1 The Anatomy Behind Cognitive Control 516

12.2 Cognitive Control Defi cits 518

12.3 Goal-Oriented Behavior 519

Cognitive Control Requires Working

Memory 520

Prefrontal Cortex Is Necessary for Working

Memory but Not Associative Memory 520

Physiological Correlates of Working

Memory 521

Organization Principles of Prefrontal

Cortex 524

12.4 Decision Making 526

Is It Worth It? Value and Decision

Making 527

More Than One Type of Decision

System? 531

Dopamine Activity and Reward

Processing 533

Alternative Views of Dopamine

Activity 537

12.5 Goal Planning: Staying on Task 539

Retrieval and Selection of Task-Relevant

Information 540

Multitasking 542

The Benefi ts and Costs of Goal-Based

Selection 542

12.6 Mechanisms of Goal-Based

Selection 545

Prefrontal Cortex and Modulation of

Processing 547

Inhibition of Action 549

Improving Cognitive Control Through Brain

Training 551

Box 12.1 Hot Science: Should Grandma and

Grandpa Start Gaming? 552

12.7 Ensuring That Goal-Oriented Behaviors

Succeed 554

The Medial Frontal Cortex as a Monitoring

System 554

How Does the Medial Frontal Cortex

Monitor Processing in Cognitive Control

Networks? 555

13 Social Cognition 566

13.1 Anatomical Substrates of Social

Cognition 568

13.2 Social Interactions and

Development 569

13.3 Social Behavioral Defi cits in Acquired and

Neurodevelopmental Disorders 571

13.4 Socrates’s Imperative: Know Thyself 572

Self-Referential Processing 572

Self-Descriptive Personality Traits 574

Self-Reference as a Baseline Mode

of Brain Function 575

Self-Perception as a Motivated Process 577

Predicting Our Future Mental State 579

Body Ownership and Embodiment 580

Box 13.1 Lessons From the Clinic: An Unwanted

Limb 582

13.5 Understanding the Mental States of

Others 584

Theory of Mind 585

13.6 Neural Correlates of Experience Sharing

Theory (Simulation Theory) 588

Mirror Neurons 589

Empathy 589

13.7 Neural Correlates of Mental State

Attribution Theory (Theory Theory) 596

Activity in the MPFC and Right TPJ 596

The Superior Temporal Sulcus: Integrating

Nonverbal Cues and Mental States 599

13.8 Autism Spectrum Disorder and the Mental

States of Others 601

Anatomical and Connectivity Differences

in ASD 601

Theory of Mind in ASD 602

The Default Network in ASD 603

The Mirror Neuron Network in ASD 605

13.9 Social Knowledge 608

Representations of Social Knowledge 609

Using Social Knowledge to Make

Decisions 611

Identifying Violators of Social Contracts 612

Moral Decisions 614

14 The Consciousness Problem 618

14.1 The Mind–Brain Problem 620

14.2 The Anatomy of Consciousness 622

14.3 Levels of Arousal and Consciousness 623

Box 14.1 Lessons From the Clinic: A Life Worth

Living 625

Arousal Regulation 625

14.4 The Organizational Architecture of

Complex Systems 628

Layered Architecture 628

Multiple Realizability 630

14.5 Access to Information 632

The Extent of Nonconscious Processing 636

Shifting Processing from Conscious to

Nonconscious Layers 637

14.6 The Contents of Conscious

Experience 639

The Brain’s Interpreter and the Unifi ed

Feeling of Self 640

14.7 Can Mental States Affect Brain

Processing? 640

Neurons, Neuronal Groups, and the

Contents of Consciousness 642

Interpreting Confusing Findings From the

Perspective of Layered Architecture 643

The Social Layer 644

14.8 The Contents of Animal

Consciousness 645

14.9 Sentience 648

The Unexpected, Unpredictable Quantum

World 648

The Principle of Complementarity 650

Sentience in Animals 651

Box 14.2 Hot Science: Bug Brains 652

Sentience Without a Cortex 652

14.10 Split-Brain Research as a Window Into

Conscious Experience 654

A Proposal: Bubbles, Not a Network 655

Glossary G–1

References R–1

Credits C–1

Index I–1

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